MovDisordV3, Main, Exploration, bibRecord, 002D70

Lifetime of Itrel II pulse generators for subthalamic nucleus stimulation in Parkinson's disease

Identifieur interne : 002D70 ( Main/Exploration ); précédent : 002D69; suivant : 002D71

Lifetime of Itrel II pulse generators for subthalamic nucleus stimulation in Parkinson's disease

Auteurs : Mathieu Anheim [France] ; Valérie Fraix [France] ; Stéphan Chabardès [France] ; Paul Krack [France] ; Alim-Louis Benabid [France] ; Pierre Pollak [France]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-12-15.

RBID : ISTEX:7FF8F7318E927713D8EEFABB3D43721B69AED1AE

Descripteurs français

Pascal (Inist)
- Durée vie, Générateur impulsion, Implant, Maladie de Parkinson, Noyau sousthalamique, Pathologie du système nerveux.

English descriptors

KwdEn :
- Aged, Deep Brain Stimulation (instrumentation), Electrodes, Implanted, Female, Follow-Up Studies, Humans, Implant, Lifetime, Male, Middle Aged, Nervous system diseases, Parkinson Disease (therapy), Parkinson disease, Parkinson's disease, Pulse generator, Retrospective Studies, Subthalamic Nucleus (physiology), Subthalamic nucleus, implanted pulse generator, subthalamic nucleus stimulation.
MESH :
- instrumentation : Deep Brain Stimulation.
- physiology : Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Aged, Electrodes, Implanted, Female, Follow-Up Studies, Humans, Male, Middle Aged, Retrospective Studies.

Abstract

The efficacy of bilateral subthalamic nucleus (STN) stimulation in Parkinson's disease (PD) is well‐established but little is known about the lifetime of implanted pulse generators (IPG). To investigate the lifetime of the bilaterally implanted Itrel II® (Medtronic, Minneapolis) pulse generator, the first 49 consecutive patients with PD having been operated on at our center for bilateral STN chronic stimulation were reviewed with noting of the stimulation parameters in use prior to IPG replacement. The mean electrical voltage was 3.2 ± 0.3 V, mean pulse width was 65 ± 10 μs, and mean frequency was 145 ± 16 Hz. Replacement of an IPG was anticipated in 25% due to unilateral low‐battery signaling, or end of life. In either case, replacement of the contralateral IPG was undertaken simultaneously. The mean IPG lifetime was 83 ± 14 [40–113] months. The IPG lifetime correlated with the total electrical energy delivered (P = 0.002, r = −0.496). Unilateral IPG end‐of‐life generally led to subacute worsening of contralateral parkinsonism. In 25% of patients, there was also a worsening of axial symptoms leading to potential medical emergencies such as falls (10%), aspiration pneumonia (10%), or psychosis (5%). A close monitoring of patients and an anticipation of IPG replacement in the case of a low‐battery signal are recommended. © 2007 Movement Disorder Society

Url:

DOI: 10.1002/mds.21726

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en">The efficacy of bilateral subthalamic nucleus (STN) stimulation in Parkinson's disease (PD) is well‐established but little is known about the lifetime of implanted pulse generators (IPG). To investigate the lifetime of the bilaterally implanted Itrel II® (Medtronic, Minneapolis) pulse generator, the first 49 consecutive patients with PD having been operated on at our center for bilateral STN chronic stimulation were reviewed with noting of the stimulation parameters in use prior to IPG replacement. The mean electrical voltage was 3.2 ± 0.3 V, mean pulse width was 65 ± 10 μs, and mean frequency was 145 ± 16 Hz. Replacement of an IPG was anticipated in 25% due to unilateral low‐battery signaling, or end of life. In either case, replacement of the contralateral IPG was undertaken simultaneously. The mean IPG lifetime was 83 ± 14 [40–113] months. The IPG lifetime correlated with the total electrical energy delivered (P = 0.002, r = −0.496). Unilateral IPG end‐of‐life generally led to subacute worsening of contralateral parkinsonism. In 25% of patients, there was also a worsening of axial symptoms leading to potential medical emergencies such as falls (10%), aspiration pneumonia (10%), or psychosis (5%). A close monitoring of patients and an anticipation of IPG replacement in the case of a low‐battery signal are recommended. © 2007 Movement Disorder Society</div>
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Movement Disorders (revue)

Lifetime of Itrel II pulse generators for subthalamic nucleus stimulation in Parkinson's disease

Lifetime of Itrel II pulse generators for subthalamic nucleus stimulation in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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